Puthussery Lab

Short (blue) and long wavelength (red) sensitive cones labeled by immunohistochemistry. We are studying the role of a voltage-gated potassium channel (green) that has been implicated in human retinal cone-rod dystrophy

Short (blue) and long wavelength (red) sensitive cones labeled by immunohistochemistry. We are studying the role of a voltage-gated potassium channel (green) that has been implicated in human retinal cone-rod dystrophy

Research Interests

The overall goal of our work is to understand how visual signals are encoded and transmitted through the retinal circuitry to generate signals that can be interpreted by the higher visual centers in the brain. We are also interested in how retinal connectivity and signaling is altered during the course of retinal neurodegenerative diseases. We use a variety of techniques to address our research questions including: immunohistochemistry, confocal and super-resolution microscopy, electron microscopy, patch-clamp electrophysiology and protein biochemistry.